Alignment of Gene 2 AA on Human MDR3 and MDR 1

CLUSTAL W(1.60) multiple sequence alignment



GENE2_FUGU      MALKIDTAETNGDLSHDSKDDGAKNEKKKKNKKEKPPQEPMVGPITLFRFADRWDVVLLI
MDR3_HUMAN      --MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMS
MDR1_HUMAN      --MDLEGDRNGGAKKK----NFFKLN--NKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMV
                  . ..   ..                  *  . *      .   ..**..   * . . 

GENE2_FUGU      SGTVMAMVNGTVMPLMCIVFGEMTDSFIYA----DMAQHNASG--WNSTTTILN--STLQ
MDR3_HUMAN      LGTIMAIAHGSGLPLMMIVFGEMTDKFV------DTAGNFSFP--VNFSLSLLNPGKILE
MDR1_HUMAN      VGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMN----LE
                 **. *. .*. .*** .******* *       *   . .     * .   .*    *.

GENE2_FUGU      EDMQRFAIYYSVLGFVVLLAAYMQVSFWTITAGRQVKRIRSLFFHCIMQQEISWFDVNDT
MDR3_HUMAN      EEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDT
MDR1_HUMAN      EDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDV
                *.* *.* *** .*  **.***.*****...****...**  ***.*..*** ***..* 

GENE2_FUGU      GELNTRLTDDVYKIQEGIGDKVGLLIQAYTTFITAFIIGFTTGWKLTLVILAVSPALAIS
MDR3_HUMAN      TELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLS
MDR1_HUMAN      GELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLS
                 *********. ** ******.*.  *. .** . **.**  ********.*.** * .*

GENE2_FUGU      AAFFSKVLASFTSKEQTAYAKAGAVAEEVLSAIRTVFAFSGQTREIERYHKNLRDAKDVG
MDR3_HUMAN      AAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIG
MDR1_HUMAN      AAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIG
                **  .*.*..*. **  *********** * ***** ** ** .*.*** *.*  ** .*

GENE2_FUGU      VKKAISSNIAMGFTFLMIYLSYALAFWYGSTLILNFEYTIGNLLTVFFVVLIGAFSVGQT
MDR3_HUMAN      IKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQA
MDR1_HUMAN      IKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQA
                .****..**..* .**.** *********.**..  **.**. .**** .*********.

GENE2_FUGU      SPNIQNFASARGAAYKVYSIIDNKPNIDSFSEDGFKPDFIKGDIEFKNIHFNYPSRPEVK
MDR3_HUMAN      APCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVK
MDR1_HUMAN      SPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVK
                .* *  ** ****** .. **** * ***.*  * *** *** .**  .** ****  **

GENE2_FUGU      ILNNMSLSVKSGQTIALVGSSGCGKSTTIQLLQRFYDPEEGAVFIDGHDIRSLNIRYLRE
MDR3_HUMAN      ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLRE
MDR1_HUMAN      ILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLRE
                ** .. * *.****.**** ********.**.** *** ** . .**.***  *. .***

GENE2_FUGU      MIGVVSQEPVLFATTITENIRYGRLDVTQEEIERATKESNAYDFIMNLPQKFETLVGDRG
MDR3_HUMAN      IIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERG
MDR1_HUMAN      IIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERG
                .***********.***.*** ***  ** .** .* **.***.*** **.**.****.**

GENE2_FUGU      TQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAALDKVRLGRTTIVVAHR
MDR3_HUMAN      AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHR
MDR1_HUMAN      AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHR
                .*********************************.***. ** **** * ******.***

GENE2_FUGU      LSTIRNADIIAGFSNGKIVEQGTHSQLMEIKGVYHGLVTMQTFHN-VEEENTAMSELSAG
MDR3_HUMAN      LSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSE---EFELNDE
MDR1_HUMAN      LSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEI
                ***.****.****  * ***.* * .**   *.*  **.***    .. *          

GENE2_FUGU      EKSPVEKTVSQSSIIRRKSTRGSSFAASEGTKEEKTEED---EDVPDVSFFKVLHLNIPE
MDR3_HUMAN      KAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTE
MDR1_HUMAN      DALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEA-LDESIPPVSFWRIMKLNLTE
                            * . ..**.     .    .            .* *** ....**  *

GENE2_FUGU      WPYILVGLICATINGAMQPVFAILFSKIITVFADPDRDSVRR-KSEFISLMFVVIGCVSF
MDR3_HUMAN      WPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFG-PGDDAVKQQKCNIFSLIFLFLGIISF
MDR1_HUMAN      WPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISF
                *** .**  **  ** .** *...** ** .*        ..  .   **.*. .* .**

GENE2_FUGU      VTMFLQGYCFGKSGEILTLKLRLRAFTAMMRQDLSWYDNPQNTVGALTTRLAADAAQVQG
MDR3_HUMAN      FTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQG
MDR1_HUMAN      ITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKG
                 * ****..***.***** .**   * .*.***.**.*  .*. ***.**** *****.*

GENE2_FUGU      AAGVRLATIMQNFANLGTSIIIAFVYGWELTLLILAVVPLIAAAGAAEIKLLAGHAAKDK
MDR3_HUMAN      ATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDK
MDR1_HUMAN      AIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDK
                * * *** * ** ***** ***.*.***.****.**.**.** .*  *.*.*.* * .**

GENE2_FUGU      KELEKAGKIATEAIENVRTVVSLSREPKFECLYEENLRVPYKNSQKKAHVYGLTYSFSQA
MDR3_HUMAN      KELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQA
MDR1_HUMAN      KELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQA
                **** *********** ******..* *** .* . *  **.** .***..*.*.* .**

GENE2_FUGU      MIYFAYAACFRFGAWLIEAGRMDVEGVFLVVSAVLYGAMAVGEANTFAPNYAKAKMAASY
MDR3_HUMAN      FMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAH
MDR1_HUMAN      MMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAH
                 .**.** ****** *.    *    * ** **...**.*.*   .*** *****..*. 

GENE2_FUGU      LMMLINKKPAIDNLSEEGTSPEKYDGNVHFEGVKFNYPSRPDVTILQGLNLKVKKGETLA
MDR3_HUMAN      LFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLA
MDR1_HUMAN      IIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLA
                . *.  . * **  * **  *   .**. *  * ****.*  . .**** * ****.***

GENE2_FUGU      LVGSSGCGKSTTIQLLERFYDPREGRVSLDGVNVKQLNIHWLRSQIGIVSQEPVLFDCSL
MDR3_HUMAN      LVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSI
MDR1_HUMAN      LVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSI
                *********** .*********  * * ***   *.**..***...*******.*****.

GENE2_FUGU      AENIAYGDNSRSVSMDEIL-AAKAANIHSFIEGLPQRYDTQAGDKGTQLSGGQKQRVAIA
MDR3_HUMAN      AENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIA
MDR1_HUMAN      AENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIA
                *********** ** .**. *** **** *** ** .* *. **************.***

GENE2_FUGU      RAIIRNPKLLLLDEATSALDTESEKVVQEALDQARKGRTCIVVAHRLSTIQNADCIAVFQ
MDR3_HUMAN      RALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQ
MDR1_HUMAN      RALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQ
                **..*.*..***********************.** ******.*********** * ***

GENE2_FUGU      GGVVVEKGTHQQLIAKKGVYHMLVTKQMGYHND
MDR3_HUMAN      NGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQNL
MDR1_HUMAN      NGRVKEHGTHQQLLAQKGIYFSMVSVQAGTKRQ
                .* * *.******.*.**.*  .*. * * .