Aliagn of MDR1 and MDR3 AA sequence

CLUSTAL W(1.60) multiple sequence alignment



MDR1_FUGU_      ---RYDTQAGDKGTQLSGGQ-KQRVAIARAIIRNPKL----------------LLLDEAT
MRD3_FUGU_      ---RYDTQAGDKGTQLSGGQ-KQRVAIARAIIRNPKL----------------LLLDEAT
MDR1_HUMAN      ----MDLEGDRNGGAKK----KNFFKLNNKSEKDKK------------------EKKPTV
MDR1_LEIEN      -MSRAHAAYANEGWSAP----EGGIAGKDGSTRDCSGYGSQGPLFSAEEEVKGTVVRETV
MDR1_MOUSE      ----MEFEENLKG-RAD----KNFSKMGKKSKKEKK------------------EKKPAV
MDR1_RAT_       ----MEFEEGLNG-RAD----KNFSKMGKKSKKEK-------------------EKKPAV
MDR1_CRIGR      ----MEFEEDFSG-RKD----KNFLKMGRKSKKEKK------------------EKKPVV
MDR1_CAEEL      MLRNGSLRQSLRTLDSFSLAPEDVLKTAIKTVEDYEGDNIDSNGEIKITRDAKEEVVNKV
MDR3_HUMAN      ----MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKK----------------TKTVKMI
MDR3_MOUSE      ----MELEEDLKG-RAD----KNFSKMGKKSKKEKK------------------EKKPAV
MDR3_CRIGR      ----MDLEAARNGTARRPGTVEGDFELGSISNQGRNK----------------KKKVNLI
MDR3_CAEEL      ----------MKKTKVNP---EDDITLGKFTPKPSP------------------QDSYQG
                                                                            

MDR1_FUGU_      SALDTENG----------------------------------------------------
MRD3_FUGU_      SALDTERLSIMALKIDTAETNGDLSHDSKDDGAKNEKKKKNKKEKPPQEPMVGPITLFRF
MDR1_HUMAN      SVFSMFRYS---------------------------------------------------
MDR1_LEIEN      GPIEIFRYA---------------------------------------------------
MDR1_MOUSE      GVFGMFRYA---------------------------------------------------
MDR1_RAT_       GIFGMFRYA---------------------------------------------------
MDR1_CRIGR      SVFTMFRYA---------------------------------------------------
MDR1_CAEEL      SIPQLYRYT---------------------------------------------------
MDR3_HUMAN      GVLTLFRYS---------------------------------------------------
MDR3_MOUSE      SVLTMFRYA---------------------------------------------------
MDR3_CRIGR      GPLTLFRYS---------------------------------------------------
MDR3_CAEEL      NFFDVFRDA---------------------------------------------------
                                                                            

MDR1_FUGU_      ---WDILMVTIGVLMAIVNGLVNPLMCIVFGEMTDSFIQ--------EAKLSQNHN-TSN
MRD3_FUGU_      ADRWDVVLLISGTVMAMVNGTVMPLMCIVFGEMTDSFIY--------ADMAQHNASGWNS
MDR1_HUMAN      -NWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFA--NAGNLEDLMSNITNRSDIND
MDR1_LEIEN      -DATDRVLMIAGTAFAVACGAGMPVFSFIFGRIAMDLMS---------------------
MDR1_MOUSE      -DWLDKLCMILGTLAAIIHGTLLPLLMLVFGNMTDSFT-KAEASILPSITN---QSGPNS
MDR1_RAT_       -DWLDKLCMALGTLAAIIHGTLLPLLMLVFGYMTDSFTPSRDPHSDRAITN---QSEINS
MDR1_CRIGR      -GWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFA--SVGNIPTNATNN--ATQVNA
MDR1_CAEEL      -TTLEKLLLFIGTLVAVITGAGLPLMSILQGKVSQAFIN------EQIVINNNGSTFLPT
MDR3_HUMAN      -DWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVD--------TAGNFSFPVNFSL
MDR3_MOUSE      -GWLDRLYMLVGTLAAIIHGVALPLMMLIFGDMTDSFA--SVGNVSKNSTN---MSEADK
MDR3_CRIGR      -DWQDKLFMLLGTIMAIAHGSGLPLMMIVFGEMTDKFVN--------NAGNFSLPVNFSL
MDR3_CAEEL      -DYKDYILFSGGLILSAVNGALVPFNSLIFEGIANALME--------------GESQYQN
                    . .    *   .   *   *    .   ..                          

MDR1_FUGU_      PTEFGYSNLQPLFFRFSIYYSILGFAVLVVAYLQMSLWTLTAARQAKRIRELFFHGIMQQ
MRD3_FUGU_      TTTILNSTLQEDMQRFAIYYSVLGFVVLLAAYMQVSFWTITAGRQVKRIRSLFFHCIMQQ
MDR1_HUMAN      TGFFMN--LEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQ
MDR1_LEIEN      ----GVGSAEEKAAKTSLIMVYVGIAMLIACAGHVMCWTVAACRQVARIRLLFFRAVLRQ
MDR1_MOUSE      TLIISNSSLEEEMAIYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQ
MDR1_RAT_       THTVSDTSLEEDMAMYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQ
MDR1_CRIGR      SDIFGK--LEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQ
MDR1_CAEEL      GQNYTKTDFEHDVMNVVWSYAAMTVGMWAAGQIIVTCYLYVAEQMNNRLRREFVKSILRQ
MDR3_HUMAN      SLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQ
MDR3_MOUSE      RAMFAK--LEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQ
MDR3_CRIGR      SMINPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKKIRQNFFHAILRQ
MDR3_CAEEL      GTINMP-WFSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKKYLKSVLRQ
                                      .   .              . .    .*  . . .. *

MDR1_FUGU_      DISWYDVTETGELNTRLTEWVTHIIHTPVPVTAGVVVIICGVRFPGAHDVYKIQEGIGDK
MRD3_FUGU_      EISWFDVNDTGELNTRLTD-----------------------------DVYKIQEGIGDK
MDR1_HUMAN      EIGWFDVHDVGELNTRLTD-----------------------------DVSKINEGIGDK
MDR1_LEIEN      DIGWHDEHSPGALTARMTG-----------------------------DTRVIQNGINDK
MDR1_MOUSE      EIGWFDVHDVGELNTRLTD-----------------------------DVSKINDGIGDK
MDR1_RAT_       EIGWFDVNDAGELNTRLTD-----------------------------DVSKINDGIGDK
MDR1_CRIGR      EIGWFDVHDVGELNTRLTD-----------------------------DVSKINEGIGDK
MDR1_CAEEL      EISWFDTNHSGTLATKLFD-----------------------------NLERVKEGTGDK
MDR3_HUMAN      EIGWFDINDTTELNTRLTD-----------------------------DISKISEGIGDK
MDR3_MOUSE      EIGWFDVHDVGELNTRLTD-----------------------------DVSKINEGIGDK
MDR3_CRIGR      EMGWFDIKGTTELNTRLTD-----------------------------DISKISEGIGDK
MDR3_CAEEL      DAKWFDETTIGGLTQKMSS-----------------------------GIEKIKDGIGDK
                .  * *      *  ..                                   .  * .**

MDR1_FUGU_      AGLLIQAASTFITSFVIGFVHGWKLTLVILAISPVLGLSAALYS----------------
MRD3_FUGU_      VGLLIQAYTTFITAFIIGFTTGWKLTLVILAVSPALAISAAFFSKVLASFTSKEQTAYAK
MDR1_HUMAN      IGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAK
MDR1_LEIEN      LSQGIMNGSMGVIGYIAGFVFSWELTLMMIGMMPFIIVMAAIIGSIVSKITESSRKYFAK
MDR1_MOUSE      IGMFFQSITTFLAGFIIGFISGWKLTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAK
MDR1_RAT_       LGMFFQSITTFSAGFIIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAK
MDR1_CRIGR      IGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAK
MDR1_CAEEL      IGMAFQYLSQFITGFIVAFTHSWQLTLVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAK
MDR3_HUMAN      VGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAK
MDR3_MOUSE      IGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAK
MDR3_CRIGR      VGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSTFSDKELAAYAK
MDR3_CAEEL      VGVLVGGVATFISGVSIGFYMCWQLTLVMMITVPLQLGSMYLSAKHLNRATKNEMSAYSN
                        .         *   * ***...   *                          

MDR1_FUGU_      ------------------------------------------------------------
MRD3_FUGU_      AGAVAEEVLSAIRTVFAFSGQTREIERYHKNLRDAKDVGVKKAISSNIAMGFTFLMIYLS
MDR1_HUMAN      AGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYAS
MDR1_LEIEN      AGSLATEVMENIRTVQAFGREDYELERFTKAVLYAQGRGIRKELASNLSAAVIMALMYVS
MDR1_MOUSE      AGAVAEEVLAAIRTVIAFGGQQKELERYNKNLEEAKNVGIKKAITASISIGIAYLLVYAS
MDR1_RAT_       AGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYAS
MDR1_CRIGR      AGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYAS
MDR1_CAEEL      AGKVVEETISSIRTVVSLNGLRYELERYSTAVEEAKKAGVLKGLFLGISFGAMQASNFIS
MDR3_HUMAN      AGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYAS
MDR3_MOUSE      AGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYAS
MDR3_CRIGR      AGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYAS
MDR3_CAEEL      AGGMANEVIAGIRTVMAFNAQPFEINRYAHQLNEARRMGIRKAIILAICTAFPLMLMFTC
                                                                            

MDR1_FUGU_      ------------------------------------------------------------
MRD3_FUGU_      YALAFWYGSTLILNFEYTIGNLLTVFFVVLIGAFSVGQTSPNIQNFASARGAAYKVYSII
MDR1_HUMAN      YALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKII
MDR1_LEIEN      YTVAFFFGSYLVEWGRRDMADIISTFLAVLMGSFGLGFVAPSRTAFTESRAAAYEIFKAI
MDR1_MOUSE      YALAFWYGTSLVLSNEYSIGEVLTVFFSILLGTFSIGHLAPNIEAFANARGAAFEIFKII
MDR1_RAT_       YALAFWYGTSLVLSNEYSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKII
MDR1_CRIGR      YALAFWYGTSLVISKEYSIGQVLTVFFAVLIGAFSIGQASPNIEAFANARGAAYEIFNII
MDR1_CAEEL      FALAFYIGVGWVHDGSLNFGDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVL
MDR3_HUMAN      YALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDII
MDR3_MOUSE      YALAFWYGTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKII
MDR3_CRIGR      YALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDII
MDR3_CAEEL      MAVAFWYGATLAAAGAVSSGAVFAVFWAVLIGTRRLGEAAPHLGAITGARLAIHDIFKVI
                                                                            

MDR1_FUGU_      ------------------------------------------------------------
MRD3_FUGU_      DNVRRPLDPGLVIILLKLASLLLEACRSVLVTARVSTWALWESALMQREDGFKPDFIKGD
MDR1_HUMAN      DN-----------------------------KPSIDSYS---------KSGHKPDNIKGN
MDR1_LEIEN      DR-----------------------------VPPVDIDAG----------GVPVPGFKES
MDR1_MOUSE      DN-----------------------------EPSIDSFS---------TKGYKPDSIMGN
MDR1_RAT_       DN-----------------------------EPSIDSFS---------TKGHKPDSIMGN
MDR1_CRIGR      DN-----------------------------KPSIDSFS---------KNGYKPDNIKGN
MDR1_CAEEL      DR-----------------------------KPVIDSSS---------KAGRKDMKIKGD
MDR3_HUMAN      DN-----------------------------NPKIDSFS---------ERGHKPDSIKGN
MDR3_MOUSE      DN-----------------------------KPSIDSFS---------KSGHKPDNIQGN
MDR3_CRIGR      DN-----------------------------NPKIDSFS---------ERGHKPDSIKGN
MDR3_CAEEL      DH-----------------------------EPEIKCTS---------SEGKIPEKIQGK
                                                                            

MDR1_FUGU_      ----------------KILNDMSFHVRNGQTIALVGSSGCGKSTTIQLLQRFYDPQ----
MRD3_FUGU_      IEFKNIHFNYPSRPEVKILNNMSLSVKSGQTIALVGSSGCGKSTTIQLLQRFYDPEEGAV
MDR1_HUMAN      LEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMV
MDR1_LEIEN      IEFRNVRFAYPTRPGMILFRDLSLKIKCGQKVAFSGASGCGKSSVIGLIQRFYDPIGGAV
MDR1_MOUSE      LEFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLEGVV
MDR1_RAT_       LEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPIEGEV
MDR1_CRIGR      LEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDPTEGVV
MDR1_CAEEL      ITVENVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGKI
MDR3_HUMAN      LEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTI
MDR3_MOUSE      LEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMV
MDR3_CRIGR      LDFSDVHFSYPSRANIKILKGLNLKVQSGQTVALVGNSGCGKTTTLQLLQRLYDPTEGTI
MDR3_CAEEL      LTFDGIEFTYPTRPELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMI
                                 .   .   .  *. .*  * *****.. . *. * *       

MDR1_FUGU_      -----------------------------------------------------KGS----
MRD3_FUGU_      FIDGHDIRSLNIRYLREMIGVVSQEPVLFATTITENIRYGRLDVTQEEIERATKESNAYD
MDR1_HUMAN      SVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYD
MDR1_LEIEN      LVDGVRMRELCLREWRDQIGIVSQEPNLFAGTMMENVRMGKPNATDEEVVEACRQANIHD
MDR1_MOUSE      SIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYD
MDR1_RAT_       SIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYD
MDR1_CRIGR      SIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYD
MDR1_CAEEL      TIDGVDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAACKMANAEK
MDR3_HUMAN      NIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYE
MDR3_MOUSE      SIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYD
MDR3_CRIGR      SIDGQDIRNFNVRYLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMEEIKKAVKEANAYE
MDR3_CAEEL      KLDGIPIQEYNIRWLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHE
                                                                     . .    

MDR1_FUGU_      -------KFETLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQA
MRD3_FUGU_      FIMNLPDKFETLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQA
MDR1_HUMAN      FIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQV
MDR1_LEIEN      TIMALPDRYDTPVGPVGSLLSGGQKQRIAIARALVKRPPILLLDEATSALDRKSEMEVQA
MDR1_MOUSE      FIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQA
MDR1_RAT_       FIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQA
MDR1_CRIGR      FIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQA
MDR1_CAEEL      FIKTLPNGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQ
MDR3_HUMAN      FIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQA
MDR3_MOUSE      FIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQA
MDR3_CRIGR      FIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQA
MDR3_CAEEL      FICKLSDRYDTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQT
                        . * .*     ********.*****.*. * ************  **  ** 

MDR1_FUGU_      ALDKVQTQTRAEMMGNKETLLHCLLVYVSPFMVRLGRTTIVIAHRLSTIRNADIIA----
MRD3_FUGU_      ALDKVR----------------------------LGRTTIVVAHRLSTIRNADIIA----
MDR1_HUMAN      ALDKAR----------------------------KGRTTIVIAHRLSTVRNADVIA----
MDR1_LEIEN      ALDQLIQ--------------------------RGGTTVVVIAHRLATIRDMDRIYYVKH
MDR1_MOUSE      ALDKAR----------------------------EGRTTIVIAHRLSTVRNADVIA----
MDR1_RAT_       ALDKAR----------------------------EGRTTIVIAHRLSTVRNADVIA----
MDR1_CRIGR      ALDKAR----------------------------EGRTTIVIAHRLSTVRNADIIA----
MDR1_CAEEL      ALDKAA----------------------------KGRTTIIIAHRLSTIRNADLII----
MDR3_HUMAN      ALDKAR----------------------------EGRTTIVIAHRLSTVRNADVIA----
MDR3_MOUSE      ALDKAR----------------------------EGRTTIVIAHRLSTVRNADVIA----
MDR3_CRIGR      ALDKAR----------------------------EGRTTIVIAHRLSTVRNADVIA----
MDR3_CAEEL      ALDKAS----------------------------EGRTTLCIAHRLSTIRNAS-------
                ***.                               * * . .****.*.*          

MDR1_FUGU_      -GFSNGEIVEQGTHSQLMEIK-GVYHGLVTMQSFQK-LEDLEDSDYEP--------WVAE
MRD3_FUGU_      -GFSNGKIVEQGTHSQLMEIK-GVYHGLVTMQTFHN-VEEENTAMSEL--------SAGE
MDR1_HUMAN      -GFDDGVIVEKGNHDELMKEK-GIYFKLVTMQTAGNEVELENAADESK--------SEID
MDR1_LEIEN      DGAEGSRITESGTFDELLELD-GEFAAVAKMQGVLAGDAKSGASVRD---------AKKA
MDR1_MOUSE      -GFDGGVIVEQGNHDELMREK-GIYFKLVMTQTRGNEIEPGNNAYGSQ--------SDTD
MDR1_RAT_       -GFDGGVIVEQGNHEELMKEK-GIYFKLVMTQTRGNEIEPGNNAYESQ--------SDTG
MDR1_CRIGR      -GFDGGVIVEQGNHEELMREK-GIYFKLVMTQTAGNEIELGNEVGESK--------NEID
MDR1_CAEEL      -SCKNGQVVEVGDHRALMAQQ-GLYYDLVTAQTFTDAVDSAAEGKFSRENSVARQTSEHE
MDR3_HUMAN      -GFEDGVIVEQGSHSELMKKE-GVYFKLVNMQTSGSQIQSEEFELND----------EKA
MDR3_MOUSE      -GFDGGVIVEQGNHDELMREK-GIYFKLVMTQTAGNEIELGNEACKSK--------DEID
MDR3_CRIGR      -GFEDGVIVEQGSHSELMQKE-GVYFKLVNMQTSGSQILSQEFEVELS--------EEKA
MDR3_CAEEL      ------------THDELISKDDGIYASMVKAQEIERAKEDTTLDDEEDEK-THRSFHRDS
                                *.    * .  .   *                            

MDR1_FUGU_      KSQLIESFSQSSLQRRRSTRGSLLAV----SEGTKEEKEKFECDQDNIEEDENVPPVSFF
MRD3_FUGU_      KSPVEKTVSQSSIIRRKSTRGSSFAA----SEGTKEEK---------TEEDEDVPDVSFF
MDR1_HUMAN      ALEMSSNDSRSSLIRKRSTRRSVRGS----QAQDRKLSTK-------EALDESIPPVSFW
MDR1_LEIEN      SGHLGVILDEADLAQLDEDVPRTARQ----NVPIDELAK----------WEVKHAKVGFL
MDR1_MOUSE      ASELTSEESKSPLIR-RSIYRSVHRK----QDQERRLSMK-------EAVDEDVPLVSFW
MDR1_RAT_       ASELTSEESKSPLIR-RSIRRSIHRR----QDQERRLSSK-------EDVDEDVPMVSFW
MDR1_CRIGR      NLDMSSKDSASSLIRRRSTRRSIRGP----HDQDRKLSTK-------EALDEDVPPISFW
MDR1_CAEEL      GLSRQASEMDDIMNRVRSSTIGSITNGPVIDEKEERIGKDALSRLKQELEENNAQKTNLF
MDR3_HUMAN      ATRMAPNGWKSRLFR-HSTQKNLKNS----QMCQKSLDVET------DGLEANVPPVSFL
MDR3_MOUSE      NLDMSSKDSGSSLIRRRSTRKSICGP----HDQDRKLSTK-------EALDEDVPPASFW
MDR3_CRIGR      ADGMTPNGWKSHIFR-NSTKKSLKSS----RAHHHRLDVDA------DELDANVPPVSFL
MDR3_CAEEL      VTSDEERELQQSLAR-DSTRLRQSMISTTTQVPEWEIENAR-----EEMIEEGAMEASLF
                            . .                                   .         

MDR1_FUGU_      KVMRYNVSEWPYILVGTICAMINGAMQPVFSIIFTEIIM---------------------
MRD3_FUGU_      KVLHLNIPEWPYILVGLICATINGAMQPVFAILFSKIITDL-------------------
MDR1_HUMAN      RIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVF---TRIDDPETKRQNSNLF
MDR1_LEIEN      RLMRMNKDKAWAVALGILSSVVIGSARPASSIVMGHMLRVLGEYSATKDVEALRSGTNLY
MDR1_MOUSE      RILNLNLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIVGVF---SRDDDHETKRQNCNLF
MDR1_RAT_       QILKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVF---SRDDDHETKQRNCNLF
MDR1_CRIGR      RILKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVF---TRNTDDETKRHDSNLF
MDR1_CAEEL      EILYHARPHALSLFIGMSTATIGGFIYPTYSVFFTSFMNVF---AGNPADFLSQG--HFW
MDR3_HUMAN      KVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIF---GPGDD-AVKQQKCNIF
MDR3_MOUSE      RILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVF---TNGGPPETQRQNSNLF
MDR3_CRIGR      KVLKLNKTEWPYFVVGTVCAIVNGALQPAISIILSEMIAIF---GPGDD-AVKQQKCNLF
MDR3_CAEEL      DIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKIL---SAGGDD--VSIKALLN
                 .            .    .   *   *  ..                            

MDR1_FUGU_      ------------------------------------------------------------
MRD3_FUGU_      ----------------------------------------------SWYDNPQNTVGALT
MDR1_HUMAN      SLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALT
MDR1_LEIEN      APLFIVFAVANFSGWILHG-FYGYAGEHLTTKIRVLLFRQIMRQDINFFDIPGRDAGTLA
MDR1_MOUSE      SLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDDHKNSTGSLT
MDR1_RAT_       SLLFLVMGMISFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDHKNTTGSLT
MDR1_CRIGR      SLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALT
MDR1_CAEEL      ALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLSQHIGFFDSPQNASGKIS
MDR3_HUMAN      SLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALS
MDR3_MOUSE      SLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALT
MDR3_CRIGR      SLVFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDYKNSTGALS
MDR3_CAEEL      SLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSLT
                                                                            

MDR1_FUGU_      ------------AAGVRLAVMTQNFANLGTSIIIS--FVYGWELTLLILAVVPILAVAGA
MRD3_FUGU_      TRLAADAAQVQGAAGVRLATIMQNFANLGTSIIIA--FVYGWELTLLILAVVPLIAAAGA
MDR1_HUMAN      TRLANDAAQVKGAIGSRLAVITQNIANLGTGIIIS--FIYGWQLTLLLLAIVPIIAIAGV
MDR1_LEIEN      GMLSGDCEAVHQLWGPSIGLKVQTMCIIASGLVVG--FIYQWKLALVALACMPLMIGCSL
MDR1_MOUSE      TRLASDASSVKGAMGARLAVVTQNVANLGTGVILS--LVYGWQLTLLLVVIIPLIVLGGI
MDR1_RAT_       TRLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVLVYGWQLTLLLVVIIPLIVLGGI
MDR1_CRIGR      TRLANDAGQVKGATGARLAVITQNIANLGTGIIIS--LIYGWQLTLLLLAIVPIIAIAGV
MDR1_CAEEL      TRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLA--FFYGWQMALLIIAILPIVAFGQY
MDR3_HUMAN      TRLATDAAQVQGATGTRLALIAQNIANLGTGIIIS--FIYGWQLTLLLLAVVPIIAVSGI
MDR3_MOUSE      TRLANDAAQVKGATGSRLAVIFQNIANLGTGIIIS--LIYGWQLTLLLLAIVPIIAIAGV
MDR3_CRIGR      TRLATDRAQVQGATGTRLALIAQNTANLGTGIIIS--FIYGWQLTLLLLSVVPFIAVSGI
MDR3_CAEEL      SRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVA--FYYGWNMAPIGLATELLLVVVQS
                                           . . . .     * * .. . .     .     

MDR1_FUGU_      AEVKLLTGHAAEDKKELEMAGK--------------------------------------
MRD3_FUGU_      AEIKLLAGHAAKDKKELEKAGKIATEAIENVRTVVSLSREPKFECLYEENLRVPYKNSQK
MDR1_HUMAN      VEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLR
MDR1_LEIEN      TRRLMINGYTK--SREGDTDDTIVTEALSNVRTVTSLNMKEDCVEAFQAALREEAPRSVR
MDR1_MOUSE      IEMKLLSGQALKDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYAQSLQVPYRNAMK
MDR1_RAT_       IEMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALK
MDR1_CRIGR      VEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALK
MDR1_CAEEL      LRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYENFCEKLDIPHKEAIK
MDR3_HUMAN      VEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQ
MDR3_MOUSE      VEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMK
MDR3_CRIGR      VEMKMLAGNAKRDKKALEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHEPYRNSVQ
MDR3_CAEEL      SVAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIV
                                                                            

MDR1_FUGU_      ------------------------------------------------------------
MRD3_FUGU_      KAHVYGLTYSFSQAMIYFAYAACFRFGAWLIEAG--RMDVEGVFLVVSAVLYGAMAVGEA
MDR1_HUMAN      KAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHK--LMSFEDVLLVFSAVVFGAMAVGQV
MDR1_LEIEN      KGIIAGGIYGITQFIFYGVYALCFWYGSKLIDKG--EAEFKDVMIASMSILFGAQNAGEA
MDR1_MOUSE      KAHVFGITFSFTQAMMYFSYAACFRFGAYLVAQQ--LMTFENVMLVFSAVVFGAMAAGNT
MDR1_RAT_       KAHVFGITFAFTQAMIYFSYAACFRFGAYLVARE--LMTFENVMLVFSAVVFGAMAAGNT
MDR1_CRIGR      KAHVFGITFSFTQAMMYFSYAACFRFGAYLVARE--LMTFENVLLVFSAIVFGAMAVGQV
MDR1_CAEEL      EAFIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPMRVLRVMYAITISTSTLGFA
MDR3_HUMAN      KAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNG--HMRFRDVILVFSAIVFGAVALGHA
MDR3_MOUSE      KAHVFGITFFFTQAMMYFSYAACFRFGAYLVTQQ--LMTFENVLLVFSAIVFGAMAVGQV
MDR3_CRIGR      MAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNG--HMRFRDVILVFSAIVFGAVALGHA
MDR3_CAEEL      RGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNN--WSTPYTVFQVIEALNMASMSVMLA
                                                                            

MDR1_FUGU_      -------------------------------------EKYDGNVLFEDVKFNYPSRPDVP
MRD3_FUGU_      NTFAPNYAKAKMAASYLMMLINKKPAIDNLSEEGTSPEKYDGNVHFEGVKFNYPSRPDVT
MDR1_HUMAN      SSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIP
MDR1_LEIEN      GAFATKLADAEASAKRVFSVIDRVPDVD-IEQAGNKDLGEGCDIEYRNVQFIYSARPKQV
MDR1_MOUSE      SSFAPDYAKAKVSASHIIRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRPNIP
MDR1_RAT_       SSFAPDYAKAKVSASHIIGIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVKFNYPTRPNIP
MDR1_CRIGR      SSFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIP
MDR1_CAEEL      TSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGEK-KKLYGKVIFKNVRFAYPERPEIE
MDR3_HUMAN      SSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVP
MDR3_MOUSE      SSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGFVFNYPTRPSIP
MDR3_CRIGR      SSFAPDYAKAKLSAAHLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANMP
MDR3_CAEEL      ASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTG-DTPTIKGNINMRGVYFAYPNRRRQL
                                                           .      * *  *    

MDR1_FUGU_      VLQGLNLEVQKGETLALVGSSGCGKSTTIQLLERFYDPREGRVLLDGVDVKQLNVHWLRS
MRD3_FUGU_      ILQGLNLKVKKGETLALVGSSGCGKSTTIQLLERFYDPREGRVSLDGVNVKQLNIHWLRS
MDR1_HUMAN      VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRA
MDR1_LEIEN      VLASVNMRFGDATSNGLIGQTGCGKSTVIQMLARFYERRSGLISVNGRDLSSLDIAEWRR
MDR1_MOUSE      VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRA
MDR1_RAT_       VLQGLSFEVKKGQTLRLVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQCVRA
MDR1_CRIGR      VLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRA
MDR1_CAEEL      ILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGEIFIDGSEIKTLNPEHTRS
MDR3_HUMAN      VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRA
MDR3_MOUSE      VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRA
MDR3_CRIGR      VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNIQWLRA
MDR3_CAEEL      VLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRD
                .*           .  *.* .****** . .. *.*    * . .       *     * 

MDR1_FUGU_      QIGIVSQEPVLFDCSLAENIAYGDNSRSVSMDEIVAAAKAANIHSFIEGLPQVAA-----
MRD3_FUGU_      QIGIVSQEPVLFDCSLAENIAYGDNSRSVSMDEIVACC----------------------
MDR1_HUMAN      HLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGD
MDR1_LEIEN      NISIVLQEPNLFSGTVRENIRYAREG--ATDEEVEEAARLAHIHHEIIKWTDGYDTEVGY
MDR1_MOUSE      HLGIVSQEPILFDCSIAENIAYGDNSRAVSHEEIVRAAKEANIHQFIDSLPDKYNTRVGD
MDR1_RAT_       -LGIVSQEPILFDCSIAENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYNTRVGD
MDR1_CRIGR      HLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGD
MDR1_CAEEL      QIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLANIHNFIAELPEGFETRVGD
MDR3_HUMAN      QLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGD
MDR3_MOUSE      QLGIVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGD
MDR3_CRIGR      QLGIVSQEPVLFDCSIAENIAYGDNSRVVSQDEIVRAAKAANIHPFIETLPQKYKTRVGD
MDR3_CAEEL      NIALVGQEPTLFNLTIRENITYGLEN--ITQDQVEKAATLANIHTFVMGLPDGYDTSVGA
                 . .* *** **  .. *** *       .  ..  ..                      

MDR1_FUGU_      ------------------------------------------------------------
MRD3_FUGU_      ------------------------------------------------------------
MDR1_HUMAN      KGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD--KAREGRTCIV
MDR1_LEIEN      KGRALSGGQKQRIAIARGLLRRPRLLLLDEATSALDSVTEAKVQEGIEAFQAKYKVTTVS
MDR1_MOUSE      KGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD--KAREGRTCIV
MDR1_RAT_       KGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD--KAREGRTCVV
MDR1_CRIGR      KGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD--KAREGRTCIV
MDR1_CAEEL      RGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKVVQEALD--RAREGRTCIV
MDR3_HUMAN      KGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALD--KAREGRTCIV
MDR3_MOUSE      KGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD--KAREGRTCIV
MDR3_CRIGR      KGTQLSGGQKQRLAIRRALIRQPRVLLLDEATSALDTESEKVVQEALD--KAREGRTCIV
MDR3_CAEEL      SGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALD--KARLGRTCVV
                                                                            

MDR1_FUGU_      ---------------------------------------------------
MRD3_FUGU_      ---------------------------------------------------
MDR1_HUMAN      IAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTKRQ
MDR1_LEIEN      IAHRLTTIRHCDQIILLDSGCIIEQGSHEELMALGGEYKTRYDLYMSALS-
MDR1_MOUSE      IAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMV--QAGAKRS
MDR1_RAT_       IAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQKGIYFSMV--QAGAKRS
MDR1_CRIGR      IAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQAGAKR-
MDR1_CAEEL      IAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSEKGAYYKLTQKQMTEKK-
MDR3_HUMAN      IAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQNL
MDR3_MOUSE      IAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQAGAKRS
MDR3_CRIGR      IAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVNIQAGAQNS
MDR3_CAEEL      IAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS----