Analysis of Influenze A Virus Neuraminidase
The H7N9 subtype influenza A virus jumped from bird to human is causing health problem in several areas in China. Neuraminidase is a key protein for virus infection. We take this as an example to make analysis using several bioinformtics tools.
- Find the amino acid sequence of different subtypes of neuraminidasein UniProt.
- Make phylogenetic analysis of different subtypes of neuraminidase.
- Find three-dimensional strucrure of human sialidase HsNEU2
- Find three-dimensional strucrure of influenza A neuraminidase N2
- Find three-dimensional strucrure of influenza A neuraminidase N9 and
oseltamivir carboxylate complex
Virus Information Resources:
- Wiki - Wikipedia of influenza information.
- GISAID - Global Initiative on Sharing Avian Influenza Data.
- OpenFlu - A database for human and animal influenza virus.
- NCBI - NCBI influenza virus resource.
- ViralZone - SIB viral resource.
- David Goodshell, Influenza Neuraminidase.
Molecule of the Month, May 2009.
- Tang RB, Chen HL. An overview of the recent outbreaks of the avian-origin influenza A (H7N9) virus in the human. J Chin Med Assoc. 2013 May;76(5):245-8. doi: 10.1016/j.jcma.2013.04.003.
- Uyeki TM & Cox NJ. Global Concerns Regarding Novel Influenza A (H7N9) Virus Infections. N Engl J Med. 2013 Apr 11.
- Liu D, et al. Origin and diversity of novel avian infl uenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses. 2013 May 1. doi:pii: S0140-6736(13)60938-1.
- Gao R, et al. Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus. N Engl J Med. 2013 Apr 11.
- Li J, et al., Environmental connections of novel avian-origin H7N9 influenza virus infection and virus adaptation to the human. Sci China Life Sci. 2013 May 8.
- Chen Y, et al., Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome. Lancet. 2013 Apr 25. doi:pii: S0140-6736(13)60903-4.
- Wang YB, et al. Towards a better understanding of the novel avian-origin H7N9 influenza A virus in China. (unpublished mterials)
- Li CY, et al., A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir. Cell Res. 2007 Apr;17(4):357-62.