Structure analysis and homology modeling of carcinoembryonic antigen
Carcinoembryonic antigen (CEA) is a glycosylated cell surface protein.
It has seven domains in the extracellular part. All these domains have typical
immunoglobulin fold. We use this example to learn how to compare protein
structures and how to do knowledge-based homology modeling.
Search Swiss-Prot with entry name:
find out the sequence features of this molecule, use dotmatcher to draw a
dotplot to show the repeated domains of this molecule.
Search Swiss-Prot with Protein Name: carcinoembryonic antigen, and Gene Name:
CEACAM*, and Organism: Homo sapiens to find different CEA members.
- Retrieve the N-terminal domain of the above CEA members, make sequence
alignment and construct a phylogeny tree.
- Make multiple sequence alignment among the N-terminal domain of CEAM5_HUMAN
and the first domain of CD2
as well as the variable domain of the light chain of immunoglobulin
- Download the crystal structure of CEAM5
from PDB,, use Swiss PDBViewer to compare the stricture features of these
- CEA Family
- A website of CEA gene family with protein domain structure of individual members.
- CEACAM5 expression profiles at Human Protein Atlas
- AAAAA - AHo's Amazing
Atlas of Antibody Anatomy (Switzerland)
- Antibody Antigen Information Resource